After graduating from college in 1985 with a degree in painting, Frank spent several years painting houses and working as a picture framer, making paintings at nights and on weekends. A native of New England and an avid outdoorsman, Frank spent those years painting outside in all seasons working from the coast to the mountains.

For two months in 1986, he backpacked 350 miles of the Appalachian Trail through the mountains of New Hampshire and Vermont. Carrying his oil painting equipment and the bare necessities in a fifty pound backpack, he created fifteen paintings en route. A small home-made easel/box that could also store three wet paintings enabled Frank to continue on his way and mail the work home as it dried.
Years later his interest shifted to creating small abstract paintings, which he would work on several at one time. After painting literally hundreds of these small pieces, the work ultimately evolved into being night images of cities and county fairs, depicting artificial light and mysterious silhouettes. These paintings sharpened his sensitivity for color and light and pushed further his ability to portray subtle emotion and atmosphere within the landscape format.

From 2000 through 2003 Frank used all the skills and vision he developed through plein-air landscape painting in combination with the shear scale and physical demands of house painting to create the murals for the Great Falls Discovery Center, a US Fish & Wildlife Nature Center in Turners Falls, Massachusetts. Eleven murals totaling 2000 square feet depicting various habitats along the Connecticut River Watershed from the Canadian border to Long Island Sound were created for the space.

In 2002, Frank received a percent-for-art commission from the state of Florida to create a piece of public art for the Palm Beach County Health Department 's new building in
West Palm Beach.
There he created two large "puzzle" paintings depicting the city of West Palm Beach and a quiet nearly empty beach, cut into silhouettes of recognizable shapes, surrounded by other paintings shaped like the continents.
Currently, Frank is again focusing on his first love, plein-air painting of the New England landscape. The experience of painting 2000 square feet of highly accurate habitat murals taught him many things about painting the landscape that he is now using in his on site landscape paintings.
Frank lives in Greenfield, Massachusetts with his wife and their two daughters.
Frank Gregory Studios occupies two floors of an old mill building on the Green River where he also operates
Green River Frameworks, a fully equipped custom frame and woodworking shop. When he is not outside painting the landscape or framing someone elses artwork he is working on his old house, playing guitar, helping with homework or listening to his family's horse riding stories.